I’ve had a lot of problems lately with Save for Web producing colors that are slightly different than my source PSD. After finally losing my mind I set out to find a solution. The most direct discussion about the issue I could find was at www.viget.com. The gist of the article discusses doing these three things:
- Close anything that is open in Photoshop and click Edit > Color Settings. From there switch the color profile to Monitor Color and uncheck Ask When Opening.
- Click View > Proof Setup > Monitor RGB
- Now when clicking Save for Web, uncheck Convert to sRGB. This item may be a check box or underneath the little arrow on the top right depending on Photoshop version
For me, these changes did the trick, now my gifs and jpgs are as close to the original as my compression settings will allow.
MUCH more discussion in the comments here: